Postdoctoral Fellow – Lipotoxicity and Liver Inflammation Laboratory

Company: Mayo Clinic
Location: Rochester
Posted on: March 23, 2026

Job Description:

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. Benefits Highlights • Medical: Multiple plan options. • Dental: Delta Dental or reimbursement account for flexible coverage. • Vision: Affordable plan with national network. • Pre-Tax Savings: HSA and FSAs for eligible expenses. • Retirement: Competitive retirement package to secure your future. Responsibilities Key Responsibilities • Conduct independent and collaborative research to investigate mechanisms of liver injury, inflammation, and vascular dysfunction in MASH. • Design and execute experiments using in vitro and in vivo models of lipotoxic liver disease. • Perform advanced molecular and cellular biology techniques, including but not limited to plasmid cloning, gene expression analysis, protein assays, and cell signaling studies. • Isolate and characterize primary liver cells, including intrahepatic leukocytes, hepatocytes and liver sinusoidal endothelial cells. • Manage and perform rodent handling and interventions, including diet-induced MASH models and genetic or pharmacologic manipulations. • Apply flow cytometry, immunohistochemistry, and immunofluorescence techniques to assess cell populations and pathological changes. • Perform basic bioinformatic analysis (e.g., RNA-seq) and interpret complex datasets. • Participate in manuscript preparation, presentations, and grant writing. What You Will Gain • Training in cutting-edge methodologies relevant to liver disease and immunometabolism. • Collaborative environment at a leading academic medical research center. • Opportunity to contribute to high-impact publications and translational research advancing therapeutic strategies for MASH. Qualifications Required Qualifications • Ph.D. in Physiology and biomedical engineering, biochemistry and Molecular Biology, Immunology, Vascular Biology, or related biomedical discipline. • Demonstrated expertise in liver pathobiology and basic molecular and mechanistic techniques. • Hands-on experience with animal handling, including approval and conduct of rodent studies. • Proven ability with plasmid cloning, gene manipulation, and cell isolation procedures. • Competence in basic bioinformatic data analysis(e.g., differential gene expression, pathway analysis). • Solid background in immunology, particularly as related to inflammation and cellular crosstalk. • Familiarity with vascular biology or endothelial cell function in organ pathology is highly desirable. Preferred Skills • Use of omics approaches to understand tissue zonation and cell interactions. • Experience in studying intercellular signaling. • Strong written and oral communication skills suitable for presentations and publications.

Keywords: Mayo Clinic, La Crosse , Postdoctoral Fellow – Lipotoxicity and Liver Inflammation Laboratory, Healthcare , Rochester, Wisconsin